ERRα-Ligand-Linker-Conjugates-1-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEERR Ligand-Linker Conjugates 1Cat. No.: HY-130499分式: CHFNO分量: 601.42作靶点: Target Protein Ligand-Linker Conjugate作通路: PROTAC储存式: -20C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外

2、实验 DMSO : 200 mg/mL (332.55 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.6627 mL 8.3137 mL 16.6273 mL5 mM 0.3325 mL 1.6627 mL 3.3255 mL10 mM 0.1663 mL 0.8314 mL 1.6627 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可

3、靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 5 mg/mL (8.31 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 5 mg/mL (8.31 mM); Clear solutionBIOLOGICAL ACTIVITY物活性ERR Ligand-Linker Conjugates 1

4、 包含靶蛋雌激素相关受体 (ERR) 配体和 PROTAC linker，可募集 E31/2 Master of Small Molecules 您边的抑制剂师www.MedChemE连接酶 MDM2。ERR Ligand-Linker Conjugates 1 可于合成系列 PROTAC 分，如 PROTAC ERRalphaDegrader-1 (HY-128838)。PROTAC ERRalpha Degrader-1种 ERR 降解剂。REFERENCES1. Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor (ERR) Degradation. ACS Med Chem Lett.2019 Apr 12;10(5):767-772.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;