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Outline of Bioinorganic Chemistry,Chapter 1 Introduction Chapter 2 Alkali and Alkaline Earth Metals Chapter 3 Metalloproteins and Metalloenzymes Chapter 4 Bioinorganic Chemistry of Nonmetallic Inorganic Compounds Chapter 5 The Frontiers of Bioinorganic Chemistry,Chapter 1 Introduction,1. What is Bioinorganic Chemistry? 2. Inorganic Elements in Biological Systems 3. Biological Ligands (Biologically Important Compounds) 4. Experimental Methods (Physicochemical Methods and Biological Methods),1.1 What is Bioinorganic Chemistry?,1.1.1 Bioinorganic Chemistry is a leading discipline at the interface of chemistry and biology Many critical processes require metal ions, including respiration, much of metabolism, nitrogen fixation, photosynthesis, development, nerve transmission, muscle contraction, signal transduction, and protection against toxic and mutagenic agents. Synthetic Chemists, Spectroscopists, Electrochemists, Theoreticians, Biochemists, and molecular Biologists meet at the frontiers of chemistry and biology and are challenged by exciting problems.,1.1.2 Development of Bioinorganic Chemistry,Molecule, Cell, and Humanity elements small molecules amino acids, nucleotides,carbohydrates, fatty acids protein(enzymes), lipids, poly-carbohydrates poly-nucleotides metalloproteins (metalloenzymes), other macromolecules procaryocyte, eucaryocyte bacteria, microorganisms, plants, animals, humanity,The first symposium on bioinorganic chemistry was initiated by inorganic chemists in 1970 The first book called “ Bioinorganic Chemistry” was written by 45 authors and published in 1973,1.1.3 Current Situation,Inorganic Biochemistry: An Introduction James A. Cowan The Ohio State University 1993, 1997 Principles of Bioinorganic Chemistry Stephen J. Lippard Maqssachusett Institute of Technology Jeremy M. Berg John Hopkins School of Medicine,The International Conference on Biological Inorganic Chemistry,1983 in Florence, Italy 1985 in the Algarve, Portugal 1987 in Noordwijkerhout, The Netherlands 1989 in Cambridge, USA 1991 in Oxford, UK 1993 in La Jolla, USA 1995 in Lubeck, Germany 1997 in Yokohama, Japan 1999 in Minneapolis, Minnestoa,5th International Symposium on Applied Bioinorganic Chemistry,Metalloenzymes - Model Compounds Biomaterials Bioelectronics Metal Based Drugs Metals in Medicine Metals Toxicology and Metals in the Environment Metal Interaction with DNA and RNA Constituents Spectroscopic Applications,J. Am. Chem. Soc Biochemistry Chem. Rev Acc. Chem. Res. Annual Reports on the Progress of Chemistry Nature Science J. Inorg. Biochem,1.2 Inorganic Elements in Biological Systems,Bulk Elements: O, C, H, N, Ca, S, P, Na, K, Cl, Mg, etc. Trace Elements: Mo, Mn, Fe, Co, Cu, Zn, I, Si, etc. Ultra-trace Elements: V, Cr, Se, Br, Sn, F, etc.,1.3 Biological Ligands,Proteins, Carbohydrates, Lipid, Steroids, Nucleotides Prosthetic Groups Coenzyme B12 Bleomycin and Siderophores Complex Assembies,1.4 Methodolo
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