中国医科大学病理学英文课件8.ppt

1、第8部分. etiologyandpathogenesisoftumor、8.1 Molecular basis of oncogenesis、8.1.1 Oncogene 1. Protooncogene、oncogeneandproducts(1 proto oncogene 3360 cellulargenesthatpromotenormalcellgrowthanddifferentiation，existinnormalceenes intheformofinactivity.(2) oncogene : derivedfromprotooncogenepromoteabnorma

2、lgrowth .(3) modeofprotooncogenesactivationpointmutationchromosomalrearrangementgeneamplificationpromoterinsertion，(4) productsandfunctions 大因素： PDGF、FGF、 egfgrowthfactorreceptorssignal-transducingproteins 3360 rasnuclearregulatoryproteins 3360 myccellcycleregulatoryproteins 33660，等等8.1.2超级电源代理， 1 .

3、概念3360 cellulargenesthatexistinnormalcellsinhibitnormalgrowthandcausecellstomalignanttransformwhentheybecomeinactive MPP TGF-，BRCA-1，BRCA-1 .机械3360相干运转，删除， meth yyy8.1.3genesthatregulateapoptosisanddnarepair、genesthatregulateapoptosisbcl (b-cell lymphoma ) family : bcl-23360 inhibitapoptosisbax : in

4、duce apoptosis2. genesthatregulatednarepair :8.1.1. telomeresshortingisbe isa tumor-suppressive mechanism.2.telomerase 3360 sustainthefunctionoftelomeresabsentfrommostsomaticcellincreasedaction8.1. 5 cinogenesis，第二代， 8.2环境保护技术支持机构， 8.2.1 cheminalcarcinogenicagentsindirect-actingagentpolycyclichydroc

5、arbons 3360信息技术支持服务器配置关系kin、lung、stomach carcinoma (2) aromaticaminesandazodyes :刀片式服务器、hepatocellularcarcinoma (3) aflatoxin 3360 potenthepatocar nitrosamines:lung，gastric， esophagagen2. direct-acting代理(1) alkylatingandacylatingagents :安ticancerdrugscyclophosphamide (2) othersarsenicskincarcinomach

6、romicalungcarcinomacadmiumprostatecarcinomanickellungcarcinoma，8.2.2物流cal1. ionizing radidi colon.2.uv 3360 skin carcinoma3. others 3360 asbestosmesotheliomaartificialmammarycarcinoma，日本电视台， 8.2.3 bioma1. rnavirus :生产/安装/安装3360人造电池lleukemia/lymphoma2. DNA virus 3360 (。 HPV 3360服务质量奖励奖励奖励奖励奖励奖励奖励奖励奖励

7、奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励奖励HBV 3360 hepatocyte carcinoma3. helicobacter pylori :机会嘉宾，存储系统的b lymphoma， 8.3 inheritedpredispositiontocarcinogens1. inheritedcancersyndrome (自动文档) familialretinoblastoma2. autosomalrec

8、essivesyndromes : bloom syndrome、fanconianemia3. familial cancer : breast。 8.3.2 Tumor immunity，1.tumor antigen 3360 tumorspecificag : onlyinneoplastictumorassociatedag : CEA AFP2. antitumor immunity : mainlycellimmunitytcell : lymphotoxinkcell、macrophage : adcc3. immunesurveilance 3360 immunodi immuno suppressed4. immunotherapy : stimulatetheendds increase the function of antitumor，复习思考题1 .比较好，恶性肿瘤的区别？ 2 .高分化鳞状细胞癌的结构特征？ 3 .什么是实性癌？ 简单说明一下病理的特征吗？ 4 .异型性、分化程度及与肿瘤良恶性的关系5 .肿瘤性增生和炎症性增生