细胞周期和细胞凋亡类基因

1、细胞周期和细胞凋亡类基因GO Gl 转变 (GO to Gl transition) 1： mdm4G1/S特异转录，有丝分裂细胞周期 (Gl/S-specific transcription in mitotic CelI CyCle) 1: gfi1Gl/S转变，有丝分裂细胞周期(Gl/S transitionOf InitOtiCCellCyCIe) 19：bcatl CCndl CCnel CdC34cdc7 cdca5 cdk4Cdkrl3 CUI1cul2cul3 cul4acul5 gsptl lats2 Pmlppp6c reel skp2Gl/S 转变检控点 (Gl/S tr

2、ansi tio n CheCkPOint) 4： ClIgl husl nbn PUraGl 期 (Gl PhaSe) 2: cdc42 rblGl期，有丝分裂细胞周期 (Gl PhaSe Of mitotic CelI CyCIe) 10： anapc2 cdc23 cdk6 CdknlC dn aja2 e2f1 map3kl1 taf1 taf11 tbrg4Gl特异转录，有丝分裂细胞周期 (GI-SPeCifiC transcription in mitotic Cell CyCIe) 1: gfiIbG2/M转变，有丝分裂细胞周期 (G2M transition Of mitoti

3、c Cel1 CyCIe) 10： anapcl anapc4 anapc5 birc5 CCnbl cdk2 dnm2 khdrbsl IatSl tpd5211G2/M转变DNA损伤检控点、(G2M transition DNA damage CheCk-POint) 1: brsklG2期，有丝分裂细胞周期 (G2 PhaSe Of mitotic CelI CyCIe) 4： CenPf CheSl gtsel kpna2M 期 (M PhaSe) 2： ilf3 rblM期，有丝分裂细胞周期 (M PhaSe Of mitotic Cel1 CyCIe) 4： cdc25b dlg7

4、 mphosph6 InPhOSPh9M 期特异微管过程 (M PhaSe SPeCifiC microtubule PrOCeSS) 1: kpna2S-M 检控点 (S-M CheCkPOint) 1: appbplS 期. 有丝分裂细胞周期 (S PhaSe Of InitOtiC CelI CyCIe) 1： cdk2aplS期特异转录，有丝分裂细胞周期 (S-PhaSe-SPeC i f ic transcriptiOn in mitotic Cell CyCIe) 1: abl1胞裂蛋白环组装(SePtin ring assembly) 1: nubpl胞质分裂 (CytOkine

5、SiS) 16： arhgef11 aurkc cecr2 dctn3 CliaPh2 espl1 myhl Pr Cl rasal rock2 sept2 sept3 sept4 sept5 sept6 sept7不对称细胞分裂(asymmetric CeI 1 division) 1： Pard3凋亡程序 (apoptotic PrOgranl) 10： bad bik casp2 casp7 casp8 casp9 mcl 1 Pdia 2 psen2 VdaCl凋亡核改变 (apoptotic nuclear ChangeS) 2： dedd2 ndufal3凋亡染色体浓缩 (apop

6、totic ChrOmOSOnle COn densation) 1: acini凋亡线粒体改变 (apoptotic mitochondrial ChangeS) 4： bakl bax bcl211 bid动粒组装 (kinetochore assembly) 2： CenPe CenPf纺锤体组织和生物发(SPindie OrganiZatiOn and biogenesis) 7： aurka bubIb cks2 kntc2 SP ag5 ube2c ZWint分裂间期，有丝分裂细胞周期(interphase Of mitotic CeII CyCle) 1: katnal减数分裂

7、(meiosis) 30： boll c8orf1 CCnal CCnb3 cspg6 dmcl dmwd duspl3 exol h2afx mrel Ia msh4 msh5 nek2 rad50 rad51 rad541 rec811 SnIClll SnIClI2 SPOll stag2 stag3 SyCPl sycp2 top3a tsga2 utpl4c xrcc2 ZWlO减数分裂纺锤体组织和生物发生 (meiotic SPindIe OrganiZatiOn and biogenesis) 1: tubgl减数分裂前期 I (meiotic PrOPhaSe I) 1： sy

8、cp2减数分裂前期 II (IneiOtiC PrOPhaSe II) 1: msh5减数分裂染色体凝集 (meiotic ChrOmOSOme SegregatiOn) 1: SgOl 1减数分裂重组 (meiotic recombination) 19： atm Chekl dmcl klhdc3 lig3 mlh3 Inrella msh4 msh5 rad21 rad50 rad51 rad5111 rad5113 rad52 rad54b rec811 SPO11 SyCPl 姐妹染色单体凝集 (SiSter ChrOmatid SegregatiOn) 1: IatSl姐妹染色单体

9、连接 (SiSter ChrOmatid COheSiOn) 3： cspg6 POIS rec811 跨越开始控制点.有丝分裂细胞周期 (traversing Start COntrOI POint Of mitotic Cell CyCIe) 6： cdc2 Cd c25c cdc6 cdc7 CdkIO cdk2联会复合体形成 (SynaPtOnemal COmPleX formation) 4： sc65 stag3 SyCPl sycp2S DN 损伤检控点 (intr-S DN damage CheCkPOint) 1: nekl 1确立有丝分裂纺锤体定位(establishmen

10、tOfmitoticSPindleIOCaIiZ-ation) 1： espl1确立有丝分裂纺锤体取向(establishmentOfmitoticSPindIeOrient-ation) 1: Pafahlbl染色体凝集 (ChrOmOSOme SegregatiOn) 13： espl1 PSenl psen2 Pttgl rad21 riok3 S gol2 SmC111 SmCIl2 SrPkl StaRl stag2 stag3染色体浓缩 (ChrOnIOSOme COndenSatiOn) 1： hilsl染色体组织和生物发(ChrOmOSOme OrganiZatiOn and

11、biogenesis) 8： Pttgl pttg3 rad50 SmClI1 SmClI2 smc211 smc511 SnIChdl染色体组织和生物发生(见于真核生物) (ChrOmOSOnIe OrganiZatiOn and biogenesis (SenSU EUkaryOta)82： abtb2 ardla atrx cbx4 CenPa Chdl chd2 chd3 chd4 cspg6 egf hlf hlfx h2 afbl h2afb3 h2afv h2afx h2afy h2afy2 h2afz h2bfm h2bfs h3f3a h3f3b h istlhlb hist

12、 Ihlc hist Ihld histlhle histlh2ab histlh2ac histlh2ae histlh2 ag histlh2ak histIh2aps4 histlh2ba histlh2bb histlh2bc histlh2bd histlh2 bh histlh2bj histlh2bk histlh2bl histlh2bm histlh2bn histlh2bo histlh3fhistlh4g hist2h2aa hist2h2ac hist2h2bc hist2h2be hist2h3c hist3h2bb hi st3h3 hmgal hmga2 loc3

13、40096 loc340549 loc347376 loc388177loc391405 IOC391769loc391770loc442461loc653604 PrnIl prm2 PSenl psen2 rad21 i'ad2111 rec811 rpl1-I96gl8.6 rp5-998n21.6 smc411 tnfrsf7 tnpl tnp2 top3a to p3b twistl znf238细胞成熟 (Cell InatUratiOn) 1:订 21细胞凋亡 (apoptosis) 262： acini ad7cntp adora2a adrala agtr2 ahr

14、aktl api5 aplpl app apr2 arhgef6 atgl2 atg5 aven axinl axudl bagl bag2 bag3bag4 bag5 bax bbc3 bcap29 bcap31 bcl2111 bcl2112 bfar bird birc4 birc5 birc6 birc7 bmf bnipl bnip2 bnip31 bnipl bre cl2orf22 CaSPI4 C asp3 casp6 casp8ap2 cdl4 cd40 cd51 cdc211 cdc212 cdkn2a cgb7 CiaPinlCiaSl Cidea Cideb CideC

15、 CIU CrOP CSeII CtnnaI1 Ctnnbl1 CyCS dadl d ap dap3 dapkl dapk2 dapk3 daxx dec ddx41 dffa dffb dhcr24 diablo di dol dnasel dnasell3 dnase2 dockl dpf2 e2f1 eaf2 ebag9 edar egln3 eif 2ak2 elmolelmo2 elmo3 ep300 ernl ern2 espllf2 f2r faf1 faimfaim2fas faslgfastkfisl fksg2 f1j21901foxo3afxrlgadd45a gadd

16、45b gadd45g gas2glrx2 gmlgpr65gzma gzmb gzmh hdhipk2 hipk3 htra2iappier3 ihpk3i117ill9 ilia illb i124il2raing4itgb2 itgb3bp kenip3 kiaa0971kiaal967IgalSl2IgaIS7 Iitaf Itbrly86 maea magehlmagi3map3k5 mdm4 moaplInrPS30mtpl8 nalp2 nckaplndufal3 nfkbl nfkbia ngfr ngfrapl nme3 nme6 ntnl p2rxl Pakl PaWr p

17、ax3 PdCdl PdCCllO PdCdl1 PdCd2 pdcd4pdcd6pdcd6ip pdcd7 pdcd8PdCI3PdeIbPhldal PhIPP PlnI PPard PPmlf PPPlrI3b PPPlrl31 PPPlrI5a ptk2b ptpn6 ptrh2 PUra PUrb rad 21 raf1 rff1ripkl ripk3rnf130 rnf34 rocklrybp SCarbl sema6aSgkSgPll sh3glblSiahl siah2Sirtl SiVa slc25a6Snlndel SPata4 spin2SqStml stkl7a stk

18、l7b stk3 stk4 SUlfl taip-2 taok2 tbrg4 tegt tesk2 tialtiaf1 tialltnf tnfaip3tnfrsfIOa tnfrsfIOctnfrsfIOd tnfrsf1Ibtnfrsf12a tnfrsf14 tnfrsf19 tnfrsfla tnfrsfIb tnfrsf21 tnfrsf25 tnfrsf6b tnf rsf7 tnfsf10 tnfsf12 tnfsf7 tnfsf9 tp53 tp53bp2 tp53inpl tp73 tp731 t radd triad3 trib3 trim35 txnl1 ube4b Im

19、 c5a unc5b unc5c unc5d yars Zb tbl6 ZdhhCI6 znf346细胞分裂 (Cell division) 138： als2crl9 anapcl anape 10 anapcl1 anapc2 anapc4 anapc5 anapc7 aspm bcarl brrnl bubl bubIb CCdCI6 ccdc5 CCnal ccna2 CCnbl ccnb2 CCnb3 CCnC CCnCll CCnd2 CCnd3 CCnel ccne2 CCnf CCngl CC ng2 CCnk CCntl ccnt2 CCrk cdcl4a cdcl6 cdc

20、2 cdc20 cdc23 cdc25a cdc25 b cdc25c cdc212 cdc216 cdc40 cdc42 cdc6 cdc7 CdCal cdca5 CdCa8 cdk2 cdk3 cdk4 cdk5 cdk6 cdk7 cdk8 CenPe CenPf CenPj Cetnl Cetn2 cetn3 Chfr Cit CkSlb cks2 ClaSPl CIaSP2apltrob cspg6 dclrela flj37927 ftsj3fzrlhcap-g incenp katnal katnbl kif11 kif23 kntcl IatSllats2Iig1 lig31

21、ig4 madlll mad211 mad212 maprel mapre2 mapre3 nedd9 neklnek2 nek3nek4 nek9 nude PafahIbI papd5 pard6a pard6b pard6gPOIS PPPlCaPPPICb PPPICC Pttgl rad21 reel rcc2 SePtl SePtlO SePtllSgOl1SgOl2 sirt2 SnIC111 smc211 smc411 spag5 SPata511 SSSCal Stagl stag2 SyCPlsycp2 taccl terfl txnl4a ube2c Weel zc3hc

22、l znf367 ZWIO细胞溶解 (CytOlySiS) 15： c5 c6 c7 c8a c8b c8g c9 gzma gzmb gzmh gzmm Iy Z mmcl Innld2 Prfl细胞生长 (Cell growth) 31： ar csrp2 ddx5 dgkd empl emp3 erbb2ip esrl fgf2O fgfrl fgfr2 fgfr3 fhl1 frapl klf6 Ieftyl Iefty2loc440836 ltbp4 mtPn ndrg4 nop5nop58 notch2 p8 slc3a2 tgfbl tgfb2 tgfb3 tnn Vatl xr

23、n2细胞死亡(Cell death) 22： aplpl aptx bnip3 CIU ClUll dbcl eif4g2 empl emp 2 emp3 faf 1 fosl2 i 117 ins nup62 parp4 PSnIC5 Ptger3 SetX tgfbl tgfb 2 Zak细胞增(Cell PrOliferatiOn) 253： ache adralb adrald akrlc3 appl ar areg arhgef1 bcarl bcatl bhlhb3 binl blzf1 bst2 btc bubl bubIb bub3 c2orf 29 cbfa2t2 cbfa2

24、t3CCkbrcdl60cd5 cd74 cdcl4a cdcl6cdc25acdc25cCdc27cdc211 cdk3 cdk4cdk5cdk5rlcdk5rapl cdk5rap3 cdk6cdk7 cdk9 CenpfChgn Chrml chrm3Chrm4 Chrnl5Cklf cks2 CIkl col4a3Cregl CriPlCSeIlCSfl CSflrcsrp2CtflCtnnbiPl cul5 CXCI1 cyr61 dab2 dctn2dipl3b dkcl dlg7 dtymke2f1e4f1eddlednra egfr eln empl emp2 enpepeph

25、b4epsl5 eps8erbb2erbb4erf erg evi5 fes fgfl fgf2fgf3 fgf4fgf5 fgf6 fgf7 fgf8fgf9figffrat2fscnl fthl fzd3 gabl gas6 gcggfer gfiIb gknl gpc4grngrprhdgfhdgfrp3 ifi16 ifrd2 igf2 igfbp4igsf8ill5ra iliai1Ibi12rail5ra il6r il8rb iI9rilk2insiglinsl4 irf2 isg20 khdrbsl kif2c kitlg klf10 krtl6 Igil ImOl IrPl

26、IrPaPl ly86 map3kl 1 maprel mapi'e2 masl matk mdk mdm4 met mia mif mki67 In natl mpl ms4a2 mt3 mtcpl mxdl myc myt2 nab2 ndp npy nr6al nrdl OSmOSmr pa2g4 PCna PdaPl Pdgfa Pdgfb Pdgfra Pemt PeSl Pgf PinIl pim2 PIkl PPard PPbP Prdm4 PrdXl prg4 Prkdl Prl Prmt5 PrOkI prok2 PSPhI PtCh Pten Ptn PUra PU

27、rb Pyy raf1 rapgef3 rbbp7 regIb reg3a retnib r fp rps27 runx3 SlOOa6 SIOOb SerPinfl Sfn shfm3pl SiPal skp2 slc29a2 sphk2 SPOCkl St订 Syk tacstd2 tall tcf19 tcf8 tfdpl tgfa tgfbl tgfb2 tgfb3 tgfbi thpo tnfrsf17 tnfsf13b tnfsf7 tnfsf8 tnfsf9 tp53 tpd5212 tpx2 traip tspanl tspan2 tspan3 tspy1 tusc2 txln

28、a txn txndc ube2v2 usp8 Vegf Vegfb VegfC VtiIb Witl Zak zfp3612 Zmyndl1 Znf259细胞周期 (Cell CyCIe) 354： ahr als2crl9 anapcl anapcl anapc11 anapc2 anapc 4 anapc5 anapc7 ankrdl5 ape appbpl appl aspm atm atr aurka aurkb au rkc axinl bax bcll binl bin3 brcal brmsl bubl bubIb CIOOrf46 cl3orf 10 c6orf88 CCdC

29、l6 ccdc5 CCnal ccna2 CCnbl ccnb2 ccnb3 CCnC CCndl CCn d2 CCnd3 CCnel ccne2 CCnf CCngl CCng2 CCnh CCnk CCntl CCnt2 CCrk Cd cl4a CdCl6 cdc2 cdc20 cdc23 cdc25a cdc25c cdc211 cdc212 cdc42 cdc451 cdc51 cdc6 cdc7 cdc73 CdCa5 cdk2 cdk2apl cdk3 cdk4 cdk5 cdk6 cdk7 cdk8 Cdknla CdknIb CdknlC Cdkn2a cdkn2b cdk

30、n2c cdkn2d cdkn3 Cdtl Ce npe Cetnl Cetn2 Cgrefl Cgrrfl ChafIa Chaflb Chekl chek2 Chfr Cit CkS Ib cks2 ClaSPl CIaSP2 CISPnaPItrOb cspg6 CtCf CtCfl CUll cul2 cul3 C ul4a cul4b cul5 cul7 Cyld dbcl dec dclrela ddit3 ddxll dipl3b died dlg7 dmbtl dmcl dtymk duspl e2fl e2f2 e2f3 e2f4 e2f6 egfr eif2ak2ep300

31、 erbb2ip escol esco2 ext 1 ext2 fancd2 fh fhit fIcn f1j37927 f Ij44060 fzrl gs2 gadd45a gak gasl gas2 gmnn gpsl gps2 grlf1 gsg2 h 2afx hcap-g hcfcl hdac4 hdac6 hid hmg20b hrasls3 hsmpp8 htatip2 ince np ingl ing4 irf1 jag2 katnal katnbl khdrbsl kif11 kif23 klkl kntclkntc2 IatSl lats2 1igl lig3 lig4 l

32、oc644162 IOhllCr2a IZtSl lzts2 ma dill mad211 mad212 mapkl mapkl2 mapkl3 mapk3 mapk4 mapk6 mapk7 InaPrelmapre2 mapre3 mcc mcm2 mcm3 mcm6 mcm7 mcm8 mdcl misl2 mki67 Inlhl mnl mnatl msh2 mtssl mutyh nat6 nbl 1 nedd9 nekl nekl1 nek2 nek3 nek4 nek9 nf1 nf2 nipblnmelnme2 nolcl nude Pafahlbl papd5 ParC pa

33、rd3Pard6aPard6bpard6gPCafPCnP PCOln3 Pfdnl Pinl PinXl Pkmytl PmSlpms2 Pnn POIS PPmId PPPlCa PPPlCb PPPlCC PtCh Pterl ptp4al Pttgl Py CarCl rad17 rad21 rad50 rapla rassf1 rblccl rbbp4 rbll rbl2 rbm22 rbm5 rcbtbl reel rcc2 reck rfp2 rgs2 rhob rif1 rintl rpll-291122.2 SIOOa6 SaShlsass6SePtlSePtlOSePtll

34、 sept2 sept3 sept4 sept5 sept6 SePt7 sept8SgOl1sgol2sh3bp4Siahl siah2 sirt2 SmarCbl SmC111 SnICIl2Smc211 smc411 smpd3 Snfllk spag5 SPin2 SSSCal Stagl stag2 stag3 Stimlstrn3 SUfU SyCPl sycp2 taccl tada21 taf1 taf11 terfl terf2 tfdpl t fdp2 tlkl tlk2 tp53 tp53bp2 tp73 tscl tsc2 tusc2 tusc4 txnl4a txnl

35、4buba52 UbelC ube2c Uhrfl uhrf2 uspl6 VaShl VhlWeel Wtl WWoX Xrnl Zak zc3hcl ZnIyn dl 1 ZWlO ZWint ZWin tas 细胞周期检控68： aif 1 apbbl apbb2 bardl btg4 ClOOrf 7 Cclknl Cdkn2b Cdkn2c Cdkn2d cdkn3 Cgrefl Cgrrfl CUll ddi t3 dhcr24 dst eif4g2 eml gadd45a gasl gas gas7 hbpl ifnwl i18 ing4 inha inhba jmy khdr点

36、 (Cell CyCIe CheCkPOint) 11: atr brcal ccne2 CCng2 Cdkn2s fancg ra dl rbl SnlC 111 tp53 Zak 细胞周期停滞 (Cell CyCIe arrest)a Cdknib CdknIC Cdkn2acul2 cul3 cul4a cul52 gas211 gas212 gas213 bsl macfl map2k6 mapkl2 mfn2 mllt7 mphosphl myc nbn notch2 pa2g4 PCa f pcbp4 Plagl1 PmI PPmlg PPPlrl5a ppp2r3b rassf1

37、 Sartl SeSnl sesn2 S esn3 tbrg4 tp53 Uhmkl VaShl Zak 雄性减数分裂(male meiosis) 3： hspa2 pim2 taf 11 雄性减数分裂 I (male meiosis I) 1： CCnal 一维细胞生长 (UnidinIenSiOrUIl CeII growth) 1： bin3 引导细胞凋亡 (induction Of apoptosis) 92： aloxl5b apoe bad bakl bax bcl10 bcl2 111 bcl2113 bclaf1 bik bnip3 bnip31 bok CaSPlO casp

38、3 casp4 casp6 cd2CiaSl Cideb CideC col4a3 dapk2 dapk3 dec dedd diablo dpf1 ei24 ere c2 ercc3 ernl ei'2 fas faslg foxo3a hd hrk ifna2 ifnbl ikbkg inha inhba jmy IaIba ICk Ita mal map3kl mapkl mxl nalpl nme3 notch2 nud t2 p8 pdcd5 PIagll Plg PmI PPPlrI3b ppp2ca ppp2rla ppp2rlb PrkCe Pten PyCard SI

39、OOb SiPal SnIndel stkl7a stk17b tial tial1 tlr2 tnfrsfIOa tnfrsf19 tnfrsf7 tnfrsf9 tnfsf10 tnfsf12 tnfsf14 tnfsf8 tp53bp2 tp731 tpd5211 tradd traf3 traip uncl3b UtPlll znf443引导细胞凋亡经死亡域受体 (induction Of apoptosis Via death dom-ain receptors) 10： bid Cradd daxx dedd dedd2 diablo fadd 1118 tnfrsf10a tnf

40、rsf10b引导细胞凋亡由胞外信(induction Of apoptosis by extracellular SignaIS) 19： adoral bax b tk casp8ap2 cd38 CfIar dap dap3 dapkl dpf2 fastk map3k5 ndufal3 PdCd 6 PrkCa ripk3 SiVa timp3 tnfrsf25 引导细胞凋亡由激素 (induction Of apoptosis by hormones) 3： Pth sstr3 tp53引导细胞凋亡由细胞信(induction Of apoptosis ul2 cul3 cul4a c

41、ul5 hipk2by intracellular SignaIS) IgalSl2 Sartl9：CdknIa CUll C引导细胞凋亡由氧化压力 (induction Of apoptosis by OXidatiVe StreSS) 2： PrOdh rnf7 有丝分裂 (mitosis) 98： akap8 anapc1 anapcl1 anapc2 anapc7 aspm aurka brrn1bubl bublb bub3 CCdCl6 CCdC5 CCnal ccna2 CCnbl ccnb2 CCnf CCngl CC ng2 CCnk cdc2 cdc20 cdc25a cd

42、c25b cdc211 cdc212 cdc6 CclCa5 cdk2 cdk3CenPf Cetnl Cetrl2 cetn3 Chfr Cit CIaSPl ClaSP2apl COrOla dclrela de tnldctn2dctn3eml4 fgf4 f1j37927fzrlhcap-ghgf incenpkatnalkatnblkif22kif23kif2c kntclIatSIlats2mad211mad212 mapre1 mapre2mapre3 misl2 nedd9 nekl nek3ek4nek9nolcl nude Pafahlblpapd5PbkPIkl POIS ppp5c Pttgl md21 rcc2 SgOll sirt2 smc211 spag5 SSSCal S taglstag2SUgtl tardbp tpx2ttntxnl4atxnl4bube2c Weelzc3hcl