已阅读5页,还剩10页未读, 继续免费阅读
版权说明:本文档由用户提供并上传,收益归属内容提供方,若内容存在侵权,请进行举报或认领
文档简介
Maintenance Therapy with 3-monthly Bacillus Calmette-Guerin for 3 Years is Not Superior to Standard Induction Therapy in High-risk Nonmuscle-invasive Urothelial Bladder Carcinoma,Ma junhai Lanzhou University Second Hospital,Journal,Contents,Introduction. Patients and methods. Results. Discussion. Limitations.,Introduction,Patients with high-risk NMIBC are usually treated with adjuvant intravesical instillations of BCG after TUR. The aim is to decrease the risk of recurrence andto a lesser extentprogression to MIBC. EU guidelines recommend standard induction therapy with once-weekly BCG instillation for 6 wk and at least 1 yr of maintenance therapy with additional instillations of BCG . BCG maintenance therapy for 3 yr following BCG induction can reduce the progression of urothelial bladder carcinoma versus BCG induction alone, but is associated with high toxicity.,Patients,Patients from the outpatient clinics of the participating centres(18) with high-risk NMIBC were randomised between October 1999 and April 2007 in Spain.,methods,1. No maintenance: BCG was instilled once-weekly for 6 wk (a total of 6 instillations). 2. Maintenance: BCG was instilled once-weekly for 6 wk, followed by maintenance therapy with a single instillation every 3 mo for 3 yr (a total of 18 instillations).,Results,Primary endpoints were disease-free interval (DFI) and time to progression (TTP). Secondary endpoints included survival duration and toxicity. Differences between treatment arms were tested using Students t test and x2 and log-rank tests.,Results,Results,Results,Results,Toxicity : 20 (10%) .,Recurrence in 40 (20%).,other reasons in 71 (35.5%). (48 received ten or more BCG instillations),Results,local side effects(safety population): frequency (65% of patients; NM 58%; M,71%), dysuria (63%; NM 57%;M69.5%); Haematuria (43%;NM, 33.5%; M 52%). general malaise (7.2%;NM, 5.8%; M 8.5%) fever (34%;NM, 27%; M, 41%).,Discussion,BCG instillation every 3 mo as maintenance therapy after the 6-wk induction course could provide sufficient immunological stimulus to avoid disease recurrence and tumour progression. For administration of a single instillation every 3mo over 3 yr, patients received 18 BCG instillations compared with 27 for the classic SWOG regimen. The lower number of instillations was associated with low toxicity. In this study we did not observe decreases in recurrence and progression rates compared with induction therapy alone. This problem is expecting for further research.,Limitations,no central pathology review; no restaging TUR; some induction patients also received short mai
温馨提示
- 1. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等,如果需要附件,请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸,网页内容里面会有图纸预览,若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对用户上传分享的文档内容本身不做任何修改或编辑,并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容,请与我们联系,我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
最新文档
- 2024年东阳市《高等数学(一)》(专升本)点睛提分卷含解析
- 湘教版八年级数学下第一章直角三角形期末复习(二)
- 新《集体劳动合同》范本
- 乐民之乐-忧民之忧教案-人教课标版
- 留在心里的印象(共10篇)
- 读一夜的工作有感(共10篇)
- 2024年照明电子产品项目发展计划
- 2021届一轮复习物质结构与性质课件(36张)
- 读书带给我的快乐(共10篇)
- 七年级上册第一单元语文教案集4-鄂教版
- 地下车库清理施工方案
- 4.混合型塑胶跑道面层施工方案【完整版】
- 新人教版必修2高中化学有机化合物教案
- 2023年武汉城投集团公开招聘【151人】上岸笔试历年难、易错点考题附带参考答案与详解
- 贵阳贵安生活垃圾转运分类分拣中心建设项目环评报告
- 2014年小儿积滞诊疗方案
- 高周波熔接机操作指导书
- DB4401-T 151-2022 装配式建筑评价标准
- 冀美2011版二年级美术下册《马戏团里的小丑》评课稿
- 幼儿园医护助教知识学习培训PPT
- 四川省成都市2023年中考数学真题卷+答案
评论
0/150
提交评论