jacs 25位副主编的研究兴趣和实验室主页

JACS 所有 25 位副主编列表： /page/jacsat/editors.html Eric V. Anslyn: Supramolecular Analytical Chemistry, small molecule therapeutics /research/sm.html Stephen J. Lippard: bioinorganic chemistry. The core activities include both structural and mechanistic studies of macromolecules as well as synthetic inorganic chemistry. The focus is on the synthesis, reactions, physical and structural properties of metal complexes as models for the active sites of metalloproteins and as anti-cancer drugs. Also included is extensive structural and mechanistic work on the natural systems themselves. A program in metalloneurochemistry is also in place. /lippardlab/ Weston Thatcher Borden: Computational Chemistry; Organic Chemistry; Organometallic Chemistry; Application of quantitative electronic structure calculations and qualitative molecular orbital theory to the understanding and prediction of the structures and reactivities of organic and organometallic compounds. /people-node/weston-t-borden Thomas E. Mallouk: Chemistry of Nanoscale Inorganic Materials: Solar Photochemistry and Photoelectrochemistry; Nanowires; Functional Inorganic Layered Materials; In-Situ Remediation of Contaminants in Soil and Groundwater Using Nanoscale Reagents /mallouk/ Benjamin F. Cravatt: Chemical Strategies for the Global Analysis of Enzyme Function; Technology Development: Activity-Based Protein Profiling (ABPP); Biological applications of ABPP - profiling enzyme activities in human cancer.; Advancing the ABPP technology; Technology Development: Protease Substrate Identification; Basic Discovery: The Enzymatic Regulation of Chemical Signaling /cravatt/research.html Chad A. Mirkin: He is a chemist and a world renowned nanoscience expert, who is known for his development of nanoparticle-based biodetection schemes, the invention of Dip-Pen Nanolithography, and contributions to supramolecular chemistry. Our research focuses on developing strategic and surface nano-optical methods for controlling the architecture of molecules and materials on a 1-100 nm scale. Our researchers, with backgrounds ranging from medicine, biology, chemistry, physics and material science, are working together in solving fundamental and applied problems of modern nanoscience. Research in the Mirkin laboratories is divided into the five areas listed below: Anisotropic Nanostructures; On-Wire Lithography (OWL); Dip-Pen Nanolithography; Organometallic Chemistry; Spherical Nucleic Acids /mirkin-group/research/ Paul Cremer: works at the crossroads of biological interfaces, metamaterials, spectroscopy, and microfluidics. Biophysical and analytical studies are tied together through the employment of novel lab-on-a-chip platforms which enable high throughput/low sample volume analysis to be performed with unprecedented signal-to-noise. From neurodegenerative diseases to artificial hip implants, a huge variety of processes occur at biological interfaces. Our laboratory uses a wide variety of surface specific spectroscopy and microfluidic technologies to probe mechanisms of disease, build new biosensors against pathogens, and understand the molecular-level details of the water layer hugging a cell membrane. Research projects in the Cremer Group are divided into the five areas listed below. Click on your area(s) of interest to learn more. SFG of Water and Ions at Interfaces; Hofmeister Effects in Protein Solutions; Bioinorganic Chemistry and Biomaterial Properties of Lipid Bilayers; pH Modulation Sensing at Biomembranes; Metamaterials /cremer/ Jeffrey S. Moore: Our research involves the synthesis and study of large organic molecules and the discovery of new polymeric materials. Most projects relate to one of three areas: new macromolecular architectures and their supramolecular organization; responsive polymers including self-healing materials; mechanochemical transduction. In general, our group uses the tools of synthetic and physical organic chemistry to address problems at the interface of chemistry and materials science. More in-depth information about our research can be found on our research page. / Lyndon Emsley: NMR http:/perso.ens-lyon.fr/lyndon.emsley/Lyndon_Emsley/Research.html Klaus Mllen: The group pursues a broad program of experimental research in macromolecular chemistry and material science. It has a wide range of research interests: from new polymer-forming reactions including methods of organometallic chemistry, multi-dimensional polymers with complex shape- persistent architectures, molecular materials with liquid crystalline properties for electronic and optoelectronic devices to the chemistry and physics of single molecules, nanocomposites or biosynthetic hybrids. http:/www2.mpip-mainz.mpg.de/groups/muellen Jean M. J. Frchet: Our research is largely concerned with functional polymers, from fundamental studies to applications. The research is highly multidisciplinary at the interface of several fields including organic, polymer, biological, and materials chemistry. Chemical Engineering is also well represented with our research in energy-related materials and microfluidics. / Eiichi Nakamura: Fascination to learn about the nature of the elements and molecules and to control their behavior goes back to ancient times. The research programs in our laboratories focus on the development of new and efficient synthetic reactions, new reactive molecules, and new chemical principles that will exert impact on the future of chemical, biological and material sciences. Under the specific projects listed below, we seek for the new paradigm of chemical synthesis and functional molecules. Discovery based on logical reasoning and imagination is the key term of our research and educational programs. http:/www.chem.s.u-tokyo.ac.jp/users/common/NakamuraLabE.html Gregory C. Fu: Transition Metal Catalysis; Nucleophilic Catalysis /research.html William R. Roush: Our research centers around themes of total synthesis, reaction development and medicinal chemistry. Over 25 structurally complex, biologically active natural products have been synthesized in the Roush lab. These serve both as testing grounds for new methods and as inspiration for potential therapeutics. Our total synthesis projects are often attempted in parallel with reaction design. Synthetic applications of intramolecular Diels-Alder reactions and acyclic diastereoselective syntheses involving allylmetal compounds are of especial interest. Total synthesis and methods development interact synergistically toward the development of medicinally relevant compounds. Current targets of interest include chemotherapeutics built upon the exploitation of tumor cell metabolism, cystein protease inhibitors for treatment of parasitic diseases and diagnostic probes for the Scripps Molecular Screening Center. /roush/Research.html Miguel Garca-Garibay: Our group is currently investigating the photochemical decarbonylation of crystalline ketones. Because the reactions take place in the solid state, they exhibit high selectivites that are not possible by the analogous solution reaction. From our experience, the solution photolysis yields many products, while there is often only one product in the solid. In order for the decarbonylation reaction to proceed in crystals, there are a few requirements for the decarbonylation precursor: (1) The compound must be a crystalline solid. (2) There must be suitable radical stabilizing substituents present at both alpha centers. /dept/Faculty/mgghome/ Alanna Schepartz: The Schepartz laboratory develops chemical tools to study and manipulate proteinprotein and proteinDNA interactions inside the cell. Our approach centers on the design of molecules that Nature chose not to synthesize-miniature proteins, -peptide foldamers, polyproline hairpins, and proto-fluorescent ligands-and the use of these molecules to answer biological questions that would otherwise be nearly impossible to address. Current topics include the use of miniature proteins to identify the functional role of discrete protein-protein interactions and rewire cellular circuits, the use of cell permeable molecules to image misfolded proteins or protein interactions in live cells, and the design of protein-like assemblies of -peptides that are entirely devoid of - amino acids. /research/index.html Martin Gruebele: The Gruebele Group is engaged in experiments and computational modeling to study a broad range of fundamental problems in chemical and biological physics. A common theme in the experiments is the development of new instruments to interrogate and manipulate complex molecular systems. We coupled experiments with quantum or classical simulations as well as simple models. The results of these efforts are contributing to a deeper understanding of RNA and proteins folding in vitro and in vivo, of how vibrational energy flows around within molecules, of single molecule absorption spectroscopy, and of the dynamics of glasses. /mgweb/ Matthew S. Sigman: Our program is focused on the discovery of new practical catalytic reactions with broad substrate scope, excellent chemoselectivity, and high stereoselectivity to access novel medicinally relevant architectures. We believe the best strategy for developing new classes of catalysts and reactions applicable to organic synthesis is using mechanistic insight to guide the discovery process. This allows us to design new reaction motifs or catalysts in which unique bond constructions can be implemented furthering new approaches to molecule construction. An underlying theme to these methodologies is to convert relatively simple substrates into much more complex compounds allowing for access to known and novel pharmacaphores in a modular manner. This provides us the ability to readily synthesis analogs enabling us to understand the important structural features responsibility for a phenotypic response in a given biological assay. We are currently engaged in several collaborative projects to evaluate our compound collections for various cancer types at the Huntsman Cancer Institute at the University of Utah and are engaged in follow-up investigations to identify improved compounds as well as understanding the mechanism of action. The group is engaged in the following diverse projects: /faculty/sigman/research.html Sidney M. Hecht: Sidney M. Hecht, PhD, is the co-director for the Center for Bioenergetics in the Biodesign Institute at Arizona State University. He researches diseases caused by defects in the bodys energy production processes. Energy production is similar mechanistically to other molecular processes that he has studied extensively. Hecht played a key role in the development of Hycamtin, a drug used to treat ovarian and lung cancer, as well as the study of the mechanism of the anti-tumor agent bleomycin. /people/sidney-hecht Donald G. Truhlar: Theoretical and Computational Chemistry We are carrying out research in several areas of dynamics and electronic structure, with a special emphasis on applying quantum mechanics to the treatment of large and complex systems. Dynamical calculations are being carried out for combustion (with a special emphasis on biofuel mechanisms) and atmospheric reactions in the gas phase and catalytic reactions in the condensed phase. Both thermal and photochemical reactions are under consideration. New orbital- dependent density functionals are being developed to provide an efficient route to the potential energy surfaces for these studies. New methods are also being developed for representing the potentials and for combined quantum mechanical and molecular mechanical methods, with a special emphasis in the latter case on improving the electrostatics. New techniques for modeling vibrational anharmonicity and for Feynman path integral calculations are also under development. /truhlar/ Joseph T. Hupp: Most research projects revolve around a theme of studying materials for alternative energy applications and other environmental issues. Due to the interdisciplinary nature of our research, we have many joint students with other researchers both at Northwestern and at other institutions. /hupp/research.html Henry S. White: My colleagues and I are engaged in both